The need for very tight particle size distributions, or specific cuts, can be critical for certain drug delivery systems, or even the efficacy of the drug itself. Inhalation therapy methods are a primary example.

Micron Technologies currently has a Hososkawa AFG 100, which is a fluidized bed opposed jet system with a classifier. For R&D studies a minimum of 500 grams is required, although a kilo of drug substance is optimal. The unit can also handle commercial quantities at a rate of 7-10 kgs/hr.

Classifying allows for a much tighter particle size distribution, with cut points down to 2 microns.